<p>Proteins in this group are involved in the transport system that mediates the uptake of a number of sugar phosphates as well as the regulatory components that are responsible for induction of this transport system by external glucose 6-phosphate. In <taxon tax_id="562">Escherichia coli</taxon> its role in transmembrane signalling may involve sugar-phosphate-binding sites and transmembrane orientations similar to those of the transport protein [<cite idref="PUB00007029"/>]. The following proteins in this entry, involved in the uptake of phosphorylated metabolites,are evolutionary related [<cite idref="PUB00002068"/>, <cite idref="PUB00005398"/>]:<ul><li>E. coli, <taxon tax_id="1423">Bacillus subtilis</taxon> and <taxon tax_id="727">Haemophilus influenzae</taxon> glycerol-3- phosphate transporter (gene glpT).</li><li> <taxon tax_id="602">Salmonella typhimurium</taxon> phosphoglycerate transporter (gene pgtP).</li><li>E. coli and S. typhimurium hexose-6-phosphate transporter (gene uhpT).</li><li>E. coli and S. typhimurium protein uhpC. UhpC is necessary for the expression of uhpT and seems to act jointly with the uhpB sensor/kinase protein.</li><li>Human glucose 6-phosphate translocase [<cite idref="PUB00001714"/>].</li></ul> </p><p>These proteins of about 50 kDa apparently contain 12 transmembrane regions.</p>This entry represents a conserved region in the central section. Glycerate/sugar phosphate transporter, conserved site